Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME AZOLE DERIVATIVES

Gollapalli Naga Raju*, Karumudi Bhavya Sai, Rangisetti Siyon Kumari, Oleti Sri Mounika, Naga Sai Rupa.R and Rama Rao Nadendla

ABSTRACT

The screening of compounds is an alternative approach to highthroughput screening for identification of leads for therapeutic targets. Some of the thiazole, triazole and tetrazole derivatives were synthesized and compounds were screened for their antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa and Salmonella typhii and pathogenic fungi like Candida albicans and Aspergilla niger by cup plate method by using Cephalosporin and Amphoterecin-B as standards. All the synthesized compounds have exhibited significant activity against the bacteria and fungi tested. All the synthesized compounds were characterized in terms of their IR and NMR spectral studies to elucidate their structures and purity.

Keywords: Thiazole, Triazole, Tetrazoles, Antibacterial activity, Antifungal activity.