Abstract

DESIGN AND EVALUATION OF SUSTAINED RELEASE TABLETS OF SALBUTAMOL SULPHATE

Murthy.P.N.V.N* and Shafiullah. D

ABSTRACT

In the present investigation sustained release matrix tablets of Salbutmol sulphate were prepared using Na CMC, Xanthan gum, HPMC100cps, Ethyl Cellulose (15cps), Compritol, Precirol in different concentrations for the treatment of bronchial disorders. Various tablet formulations were prepared and evaluated for compatibility studies and physical parameters such as Hardness, Friability, Dissolution, Content Uniformity and Thickness. The manufacturing procedure was optimized with respect to the hardness 5 to 6 kg/cm2 and description being white, oval shaped tablets with flat face on both sides. The tablet weight was targeted for 190 mg. The developed formulations showed uniform pre and post compresssional properties. Out of all formulations F5 was showed higher rate of drug release 99.87 % when compared to other formulations. Formulation containing NaCMC, Xanthan gum, HPMC100cps polymers showed higher rate of drug release over a period of 24hrs. In conclusion, the results suggest that the developed sustained release matrix tablets of Salbutamol sulphte is a potential attempt, and better than conventional dosage forms, leading to avoid dosing frequency and better patient compliance.

Keywords: Salbutamol sulphate, Precirol, HPMC and Controlled release.