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Abstract

SPECTRAL CHARACTERIZATION AND DNA BINDING PROPERTIES OF DINUCLEAR NICKEL (II) COMPLEXES WITH PYRIDINE BASED ACETOYL AND BENZOYL HYDRAZONES CONTAINING ACETATE BRIDGES

D. Nagakavitha* K. Hussain Reddy and V. Venkateswarlu

ABSTRACT

Dinuclear nickel(II) complexes of functionalized heterocyclic hydrazones, viz. 2-acetylpyridine acetoylhydrazone (APAH), 2- acetylpyridine benzoylhydrazone (APBH), 2-benzoyllpyridine acetoylhydrazone (BPAH), 2-benzoylpyridine benzoyl hydrazone (BPBH) have been synthesized and characterized on the basis of elemental analysis, molar conductivity measurements, magnetic susceptibility electronic and infrared spectral data. Complexes are found to be nonelectrolytes as evident from conductivity studies. IR spectral data suggest that the ligands act uninegative trifunctional NNO-donor system. Electronic spectral data suggest octahedral geometry for the complexes. Electrochemical behavior of metal complexes indicated quasi-reversible one electron reduction. DNA binding properties of complexes are investigated using UV- visible spectroscopy. Higher binding constants revealed that the complexes bind DNA through intercalation involving a strong π-stacking interaction between the aromatic chromophore (pyridine moiety) and base pairs of DNA.

Keywords: Synthesis, nickel(II) complexes, pyridine hydrazones, spectral studies, DNA binding properties.


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