Abstract

FORMULATION OF LAMOTRIGINE ORODISPERSIBLE TABLETS BY USING NEW GENERATION SUPERDISINTEGRANTS

B. Ramu*, N. Ramakrishna and B. Shivashanker

ABSTRACT

In the present work, an attempt has been made to develop fast disintegrating tablets of Lamotrigine. New generation super disintegrates Solutab, Explotab and Polyplasdone XL was selected as super disintegrates. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F4 formulation showed maximum % drug release i.e., 97.54 % in 10 min hence it is considered as optimized formulation. The f4 formulation contains Solutab as super disintegrate in the concentration of 20 mg.F8 formulation also showed maximum percentage drug release i.e., 101.8% in 10 min ,it contains Explotab as super disintegrate in the concentration of 20 mg.

Keywords: Lamotrigine, Oro disintegrating tablets, Explotab, Solutab, Polyplasdone XL.