Abstract

THERAPEUTIC POTENTIAL OF FIXED DOSE COMBINATIONS OF DRUGS FOR TYPE 2 DIABETES MELLITUS

Shashiraj N. Gohel*, Vipul D.Prajapati, Himanshu K. Solanki, Girish K.Jani, Kalpesh Patil and Prerna Ratnaparkhi

ABSTRACT

Obtaining the target blood glucose level by monotherapy can be challenging, especially for the patients who are suffering from other disease meanwhile. Polypharmacy is often required to achieve good metabolic control. Reducing treatment complexity can be achieved through the use of single-tablet fixed-dose combinations of two oral hypoglycemic agents. FDCs improve patient compliance by reducing the number of pills. A range of fixed dose combination oral hypoglycemic agents in several different dosage strengths are available. Clinical studies revealed that fixed-dose combinations had many benefits compared to single entity and separate agents in terms of effects, convenience, compliance, and cost. Present article includes advantages, regulatory status, criteria and risk factors for use of FDC for the type 2 diabetes mellitus treatment.

Keywords: Fixed Dose Combination, Therapeutic potential, Diabetes mellitus.