Abstract

HORMONAL AND LIPID PROFILE CHANGES IN MEN WITH CHRONIC RENAL FAILURE

Amina H. Ahmed Al-Obaidi*, Omar R. Ghayyib AL-Karkhi, Abdulghni M. Ali Al- Samarai.

ABSTRACT

Background: Chronic kidney disease (CKD) naturally progresses with metabolic and hormonal disorders. Aim:This study was conducted to determine occurrence and prevalence hormonal changes in patients with CKD. Materials and methods: We conducted a cross sectional study for a sample composed of 70 patients with CRF, admitted to the Baqubah teaching hospital,dialysis unit, their ages between (20 – 60) years, and a control group consists of 40 subjects of comparable age, selected from medical staff who were apparently normal healthy adults without any major illness. The levels of hormones assay (LH, FSH, prolactin and testosterone) were measured by VIDS automated technical. The levels of blood urea, serum creatinine, blood glucose, total protein and serum albumin as well as serum triglycerides(TG),total cholesterol( TC),low density lipoprotein cholesterol( LDL-C), very low density lipoprotein cholesterol(VLDL-C) and high density lipoprotein cholesterol(HDL) were measured by colorimetric method. TC/HDL-C and LDLC/ HDL-C ratios were calculated. Results: The levels of serum LH, FSH and prolactin were significantly increased and serum TG, VLDL-C and blood glucose were significantly increased and HDL-C,TC, LDL-C, total protein and serum albumin was significantly decreased in cases when compared to controls. Conclusion: Patients with CKD are prone to hormonal and metabolic changes with health impact that need continious follow up.

Keywords: Chronic renal failure; Hormonal change; Sex Hormones Disorder; Erectile Dysfunction.