WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

PREPARATION AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM OF ALFUZOSIN HYDROCHLORIDE

Sachin P Ghanchi*, Pankaj H Prajapati and Nadim M. R. Chhipa

ABSTRACT

Alfuzosin is selective α1-Adrenergic blocker indicated for the treatment of signs and symptoms of benign prostatic heperplasia. The present investigation was aimed to formulate and evaluate gastro retentive drug delivery system of Alfuzosin hydrochloride. Gastro retentive Alfuzosin hydrochloride (10 mg) tablet was prepared by direct compression method. The tablets were evaluated for in vitro release profile and various evaluation parameters. The floating lag time of Alfuzosin hydrochloride floating tablets were within the prescribed limit (<3 minutes). Formulation A8 (45 % HPMC K4 M, 12% EC) was selected as an optimum formulation as it shows more similarity in dissolution profile with marketed product (Similarity factor, f2= 83.05). From the present investigation it can be concluded that the gastro retentive Alfuzosin hydrochloride tablet is used to improve the absorption of drug and to reduce the frequency of administration with improved patient compliance.

Keywords: Alfuzosin hydrochloride, Gastro retentive, HPMC, Floating lag time, Higuchi Kinetics.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More