Abstract

HYPOGLYCAEMIC EFFECT AND INTERACTIONS OF ANGIOTENSIN II TYPE I RECEPTOR BLOCKER (TELMISARTAN) WITH ORAL HYPOGLYCAEMIC AGENTS IN STREPTOZOCININDUCED DIABETIC RATS

Dr. Mohd Sajid Khan (M.D)* and Dr. Arvind Kumar Gupta

ABSTRACT

Objective: To study the effect of angiotensin II receptor blocker on blood glucose level and possible interactions when combined with Oral hypoglycaemics in Streptozocin induced diabetic rats. Material & Methods: Present study performed in animal house of department of pharmacology G.S.V.M. medical college Kanpur with prior permission from Institutoinal animal ethics committee. Rats were divided into 9 groups & each group contains six rats. Diabetes was induced by a single intra peritoneal injection of streptozocin (STZ) at a dose of 60 mg/kg body weight dissolved in 0.01 M citrate buffer.Three days after STZ injection rats with blood sugar level more than 250 mg/dl were selected. Results: On comparison to diabetic control group (table 2) it was found that gliclazide exhibit significant hypoglycemia (P

Keywords: Angiotensin Receptor Blockers, Oral hypoglycemic agents, i.p.(intra peritoneal), Streptozocin.