HYPOGLYCAEMIC EFFECT AND INTERACTIONS OF ANGIOTENSIN II TYPE I RECEPTOR BLOCKER (TELMISARTAN) WITH ORAL HYPOGLYCAEMIC AGENTS IN STREPTOZOCININDUCED DIABETIC RATS
Dr. Mohd Sajid Khan (M.D)* and Dr. Arvind Kumar Gupta
ABSTRACT
Objective: To study the effect of angiotensin II receptor blocker on
blood glucose level and possible interactions when combined with Oral
hypoglycaemics in Streptozocin induced diabetic rats. Material &
Methods: Present study performed in animal house of department of
pharmacology G.S.V.M. medical college Kanpur with prior permission
from Institutoinal animal ethics committee. Rats were divided into 9
groups & each group contains six rats. Diabetes was induced by a
single intra peritoneal injection of streptozocin (STZ) at a dose of 60
mg/kg body weight dissolved in 0.01 M citrate buffer.Three days after
STZ injection rats with blood sugar level more than 250 mg/dl were
selected. Results: On comparison to diabetic control group (table 2) it
was found that gliclazide exhibit significant hypoglycemia (P<0.05)
throughout the period of observation, Metformin exhibit significant hypoglycemia (P<0.05)
at 1 and 2 hrs, pioglitazone exhibit highly significant hypoglycemia (p<0.01) throughout the
period of observation, Effect of Telmisartan on blood glucose level is significant (p<0.05)
throughout the period of observation, table 9 and fig. 2, observations indicated that
Telmisartan enhances the hypoglycemic effect of gliclazide significantly (P < 0.05).Table 11
and fig. 3, observations indicated that telmisartan enhances the hypoglycemic effect of
metformin significantly (P < 0.05). Conclusion: From this study it is evident that ARBs may
reduce the blood glucose level in normal and diabetic conditions. It was also observed that
ARBs may also induce antihyperglycemic effect of oral antidiabetic drugs in experimental
animal. It is therefore advisable to prescribe and use of ARBs with anti diabetic drugs carefully with necessary dose adjustment of doses to avoid adverse hypoglycemic episodes in
diabetic individuals.
Keywords: Angiotensin Receptor Blockers, Oral hypoglycemic agents, i.p.(intra peritoneal), Streptozocin.
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