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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

FORMULATION AND EVALUATION OF CELECOXIB LOADED MICROBEADS FOR COLORECTAL CANCER

*Vishal Lokhande1, Ranju Pal2

1Maharashtra College of Pharmacy, Brahmapuri, (M.H.) India
2Department of Pharmacy, Barkatullah University Bhopal (M.P.)

ABSTRACT

Celecoxib is a nonsteroidal anti-inflammatory drug that exhibits antiinflammatory, analgesic, and antipyretic activities. Recently, considerable interest has been focused on the use of biodegradable polymers for specialized applications such as targeted release of drug formulations; meanwhile, microbeads drug delivery systems using various kinds of biodegradable polymers have been studied extensively during the past two decades. In the present investigation, it was aimed to prepare microbead formulations of celecoxib inclusion complex using sodium alginate and eudragit FS 30-D as a carrier for colonic administration to extend the retention of the drug in order to treat colorectal cancer. Microbead formulations were evaluated for entrapment efficiency, FT-IR, DSC, SEM, In vitro drug release, In vitro cell line study, Cytotoxicity Screening. Formulation F5 showed 91.99 1.45% entrapment, which was uniformly dispersed and having smooth surface texture in formulation, F5 shown 92.112.32% drug release up to 8 hr. Coated Celecoxib microbeads (1:1ratio) showed cytotoxicity against HT-29 cells. DNA Fragmentation study confirms the better anti cancer activity of celecoxib microbeads against human colorectal adenocarcinoma cell line HT-29. Hence the formulations can be effectively tested for its anticancer activity.

Keywords: Celecoxib, targeted drug delivery, in vitro dissolution, microbeads, entrapment efficiency.


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