Abstract

MICHELIA CHAMPACA: A USEFUL REMEDY FOR MAST CELL STABILIZATION, ANTIALLERGIC AND ANAPHYLACTIC ACTIVITY IN MANAGEMENT OF ASTHMA

Dr. Anupama A. Suralkar*, Tayade G.V. and Dose R. S.

ABSTRACT

The anti-allergic, anti-anaphylactic and mast cell stabilizing activity of ethanolic extract of Michelia champaca (MC) was evaluated pharmacologically by using milk induced leukocytosis and eosinophilia in mice, compound 48/80 induced mast cell degranulation in rats and egg albumin induced passive paw anaphylaxis in rats. In the milk induced eosinophilia and leukocytosis, MC showed significant inhibition of the total number of eosinophils and leukocyte count in mice; in the compound 48/80 induced mast cell degranulation MC showed significant protection of mast cells in rats; and in passive paw anaphylaxis, MC showed significant reduction in the paw edema volume in rats. These results suggest that MC may prove to be a potential therapeutic agent in management of asthma which may be due to anti-stress, mast cell stabilizing and anti-inflammatory activity.

Keywords: Michelia champaca, milk, compound 48/80, anaphylaxis.