Abstract

A CONVENIENT ONE-POT MULTI-COMPONENT SYNTHESIS OF DIHYDROPYRIMIDO [4,5-B] QUINOLINETRIONES AND EVALUATION OF THEIR ANTICANCER ACTIVITY

Suresh C. Jadhvar, Hanmant M. Kasraliker, Santosh V. Goswami and Sudhakar R. Bhusare*

ABSTRACT

An effective protocol was developed for the synthesis of dihydropyrimido[4,5-b] quinolinetriones by one-pot four-component reaction of a substituted salicylaldehyde, 3-chloro-4-fluroaniline, dimedone and barbituric acid using ionic liquid [Msim]Cl as a catalyst. All the synthesized derivatives were evaluated for inhibition of cancer cell. The initial assays indicated that some of the newly synthesized compounds displayed significantly good inhibition activities against human breast cancer cell (MCF7), cell lines compared with the control (Adriamysin), which might be developed as novel lead scaffold for potential anticancer agents.

Keywords: anticancer activity, one-pot synthesis, salicylaldehyde, barbituric acid, [Msim]Cl, dihydropyrimido[4,5-b] quinolinetriones.