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Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL CHALCONES AND PYRAZOLINE DERIVATIVES FROM 1-(3-CHLOROPHENYL) ETHANONE

G. Eswara Rao *, P. Srinivasa Babu, J Sambrajyam, N. Sresta, Md. Shaheem Sultana, R. Lakshmi Durga, K. Srikanth

ABSTRACT

Novel chalcones were synthesized by condensing 1-(3-chlorophenyl) ethanone with aromatic aldehydes derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to Claisen - Schmidt condensation. The synthesized chalcones compounds were reacted with hydrazine sulphate upon cyclisation gives pyrazoline derivatives. All these compounds were characterized by means of their IR, 1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.

Keywords: Chalcones, Pyrazole, Synthesis, Antimicrobial activity


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