Abstract

SELF DOUBLE EMULSIFYING DRUG DELIVERY SYSTEM: A COMPREHENSIVE REVIEW

Komal Jayshankar Chourasia* and Nilesh Mahadeo Khutle

ABSTRACT

Drugs are most frequently administered by the oral route and more than 40% of new chemical entities exhibit poor aqueous solubility, resulting in unsatisfactory oral drug delivery. Hence, Self-emulsifying drug delivery system (SEDDS) are gaining much more attention in drug delivery of poorly aqueous soluble drugs exhibiting dissolution rate limited absorption. However, the modified application of SEDDS i.e., SDEDDS (Self-double emulsifying drug delivery system) are basically designed to delivery BCS Class III defined as “high aqueous solubility and low permeability class” in which gastrointestinal permeation is the rate controlling step in absorption process. Therefore improving permeability may potentially improve the bioavailability of these drugs. This review discusses the formulation, methods of preparation and evaluation of SDEDDS in brief.

Keywords: double emulsion, self-emulsifying, low permeability, self double emulsifying drug delivery system (SDEDDS).