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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

CYTOPROTECTIVE AND ANTIOXIDANT PROPERTIES OF THE STEM BARK AQUEOUS EXTRACT OF ENANTIA CHLORANTHA OLIVER (ANNONACEAE) IN RATS

Kuissu Teukam Mimosette Mesmine, Mezui Christophe, Nkwengoua Zondengoumba Ernestine and Tan Paul Vernyuy*

ABSTRACT

Enantia chlorantha is a plant used in African traditional medicine to treat many diseases including gastric ulcers. In this study, we evaluated the anti-ulcerogenic effects of the aqueous extract of the stem bark of this plant using different methods of gastric lesion induction in experimental Wistar rats (140-190 g): 1. HCl/Ethanol, 2. HCl/Ethanol/Indomethacin, 3. indomethacin, 4. absolute ethanol, 5. cold water immersion 6. Pylorus ligation. Phytochemical screening of the aqueous extract of Enantia chlorantha revealed the presence of phytoconstituents such as tannins, alkaloids, saponins, flavonoids. The extract at different doses (250 and 500 mg/kg) significantly reduced the ulcer index in all models used (67.87 % (p

Keywords: Enantia chlorantha, gastric ulcer, cytoprotection, antioxidant.

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