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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

COMPARATIVE EVALUATIONS BETWEEN CARBOPOL GEL AND PARAFFIN OINTMENT BASE FOR THE DEVELOPMENT OF TOPICAL SEMISOLID FORMULATION CONTAINING CLOTRIMAZOLE IP

*Sarath chandran C, Vipin K.V, Ann Rose Augusthy, Soumya K Vijayan, Sangeetha Vijayan U

Assistant Professor, Department of Pharmaceutics, Academy of Pharmaceutical Sciences, Pariyaram, Kerala, India.

ABSTRACT

Selection of bases is very crucial during the development of topical semisolid preparations. In this investigation an attempt has been made to compare the performance of carbopol gel and paraffin base in the delivery of Clotrimazole IP. Developed formulations were subjected for evaluation for the drug content, pH, spreadebility, extrudability, viscosity,in vitro diffusion profile and in vitro antifungal activity. Stability profile of developed formulations was subjected for investigation. Results of investigation clearly proved the superiority of carbopol gel base for the development of topical semisolid formulation containing Clotrimazole.

Keywords: Clotrimazole, in vitro diffusion, spreadebility, viscosity.

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