EVALUATION OF ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF AGANOSMA CYMOSA AND ITS ANTIOXIDANT PROPERTY IN STREPTOZOTOCIN INDUCED DIABETES RATS
*Sangeetha Jayaraman1, Abbulu Konde1, Sudhakar Muvvala2
1Department of Pharmacognosy, Malla Reddy Institute of Pharmaceutical Sciences, Secunderabad, India – 500 014.
2Department of Biotechnology, Malla Reddy College of Pharmacy, Secunderabad, India – 500 014.
ABSTRACT
The present study was carried out to illustrate the antidiabetic potential
of ethanolic extract of Aganosma cymosa and to establish its
antioxidant property. The antidiabetic activity of ethanolic extract of
Aganosma cymosa in two different doses (200mg/kg and 400mg/kg,
b.w.) was compared with standard Glibenclamide. The treatment for 28
days with standard and test doses showed significant (P<0.05) decrease
in the blood glucose level. Test dose 2 (400mg/kg, b.w.) showed
highly significant (P<0.0001) results when compared to diabetic
control. The increased serum triglycerides, total cholesterol and
Bilirubin levels were found decreased in standard and test dose treated
groups, while the HDL level in the treated group was found elevated.
The serum enzymes Aspartate aminotransferase (AST), Alanine
aminotransferase (ALT) and Alkaline phosphatase (ALP) were found significantly reduced
when compared to diabetic control. The results were supported with the Histopathological
studies of the pancreas, which showed remarkable changes in the restoration of islets of
langerhans. The plant extract also exhibited a very good antioxidant activity by maintaining
the levels of Catalase (CAT), Superoxide Dismutase (SOD), Reduced Glutathione (GSH),
Glutathione peroxidase (GPx) and Lipid peroxidase (LPO).
Keywords: Antidiabetic activity, in-vivo antioxidant activity, Aganosma cymosa, serum enzymes.
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