WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

EVALUATION OF ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF AGANOSMA CYMOSA AND ITS ANTIOXIDANT PROPERTY IN STREPTOZOTOCIN INDUCED DIABETES RATS

*Sangeetha Jayaraman1, Abbulu Konde1, Sudhakar Muvvala2

1Department of Pharmacognosy, Malla Reddy Institute of Pharmaceutical Sciences, Secunderabad, India – 500 014.
2Department of Biotechnology, Malla Reddy College of Pharmacy, Secunderabad, India – 500 014.

ABSTRACT

The present study was carried out to illustrate the antidiabetic potential of ethanolic extract of Aganosma cymosa and to establish its antioxidant property. The antidiabetic activity of ethanolic extract of Aganosma cymosa in two different doses (200mg/kg and 400mg/kg, b.w.) was compared with standard Glibenclamide. The treatment for 28 days with standard and test doses showed significant (P<0.05) decrease in the blood glucose level. Test dose 2 (400mg/kg, b.w.) showed highly significant (P<0.0001) results when compared to diabetic control. The increased serum triglycerides, total cholesterol and Bilirubin levels were found decreased in standard and test dose treated groups, while the HDL level in the treated group was found elevated. The serum enzymes Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) were found significantly reduced when compared to diabetic control. The results were supported with the Histopathological studies of the pancreas, which showed remarkable changes in the restoration of islets of langerhans. The plant extract also exhibited a very good antioxidant activity by maintaining the levels of Catalase (CAT), Superoxide Dismutase (SOD), Reduced Glutathione (GSH), Glutathione peroxidase (GPx) and Lipid peroxidase (LPO).

Keywords: Antidiabetic activity, in-vivo antioxidant activity, Aganosma cymosa, serum enzymes.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More