Abstract

CHEMOPREVENTIVE EFFECT OF OCTYL GALLATE AND GALLIC ACID ISOLATED FROM METHANOLIC EXTRACT OF TERMINALIA BELLARICA FRUIT ON DMBA INDUCED MAMMARY CARCINOMA

Manikkam Rajalakshmi* and Mary Selesty Sales

ABSTRACT

Introduction: Octyl gallate (OG) and gallic acid (GA) are molecules with significant biological activities and are widely present in several plants. The present study was aimed to determine the potentials of OG and GA isolated from the methanolic extract of Terminalia bellarica (T. bellarica) fruit against DMBA induced breast cancer in female Sprague-Dawley rats. Methods: The level of RBC, WBC and platelets in the normal, cancer and compound treated rats were analyzed using automated cell counter. Tumor markers CEA and CA 15.3 in the serum of all the experimental groups were analyzed using specific kits. Change in the tissue morphology and cell patterns in breast tissue was examined by histological studies. Results: All the blood parameters of study (RBC, WBC and platelets) were found to be in lowers levels compared to the normal. The tumor markers (CEA and CA 15.3) were found to be elevated in cancer controls. These changes in blood cell count and tumor markers in DMBA induced rats were found to be prevented and maintained in a normal range upon OG and GA supplementation. The compounds also inhibited the induction of breast cancer by DMBA showing normal tissue morphology and cell pattern when compared to the abnormal tissue morphology in cancer control. Conclusion: Hence the present study suggest OG and GA as effective molecules with chemopreventive property against breast cancer and these compounds with further studies can be used as chemopreventive agents against breast cancer.

Keywords: Introduction: Octyl gallate (OG) and gallic acid (GA) are molecules with significant biological activities and are widely present in several plants. The present study was aimed to determine the potentials of OG and GA isolated from the methanolic extract