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Abstract

SIMULTANEOUS ESTIMATION OF ALOGLIPTIN AND METFORMIN FROM ITS TABLET DOSAGE FORM BY AREA UNDER CURVE AND MULTICOMPONENT UV SPECTROPHOTOMETRIC METHOD

*Ana Nikalje, Mirza Shahed Baig, Mohammed Imran Anees, Afaq Qureshi.

ABSTRACT

Two simple, accurate and precise UV methods were developed for the estimation of Alogliptin (ALO) and Metformin (MET) in Tablet dosage form. Both the drugs are used as Antidiabetic Drug. Method A is Area under Curve Spectrophotometry and in this the wavelength range selected for Quantitation are 215 – 240nm for Alogliptin and 265 - 293nm for Metformin. Method B is Multicomponent mode wavelength selected for Quantitation method were MET and ALO therefore for 284nm (λ max of MET) and 274 (λ max of ALO) for the analysis. In both the methods linearity for detector response was observed in the concentration range of 10-50 microgram/ml for MET and ALO respectively. The results of tablet analysis for Area under Curve was found to be 99.90 ± 0.151 for ALO and 99.62 ± 0.220 for MET and results obtained for Multicomponant was 99.73 ± 0.306 for ALO and 99.30 ± 0.224 for MET. The proposed methods were successfully applied for the Simultaneous determination of both the drugs in bulk as well as commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies which were according to ICH guidelines.

Keywords: Alogliptin, Metformin, UV-Spectrophotometry, Area under Curve, Multicomponent mode method.


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