Abstract

HISTOLOGICAL & HISTOCHMICAL CHANGES IN LIVER OF ADULT RATS TREATED WITH MONOSODIUM GLUTAMATE: A LIGHT MICROSCOPIC STUDY

Vandana Kumbhare, Ujwal Gajbe, Brij Raj Singh, *Anil Kumar Reddy,
Samarth Shukla

ABSTRACT

Introduction: Monosodium Glutamate, also known as MSG.[1-3] Monosodium glutamate is a controversial additive. It is metabolized in liver and kidney plays an important role in its elimination.[4] In 1968 Schaumburg H.H and R. Byck[5] were the first people to draw attention towards Chinese restaurant syndrome characterized by headache, chest discomfort and facial flushing.[6, 7, 8] The diversity in manifestation of toxic effects and susceptibility of different species of animals to MSG was such that till date no specific dietary limitations have been recommended. The current research work is carried out to Study the morphology and histology of adult rat liver treated with Monosodium Glutamate (3mg and 6mg/gm body weight). Materials & Methods: The study was started after permission from Institutional Ethical committee which has duly authorized CPCSEA approval for animal experiment. In all 51 adult Wistar rats were assigned into three study groups randomly. All three group experimental animal were sacrificed according to CPCSEA guideline, and Liver tissue sample were taken for morphological and histological examination. Conclusion: The findings revealed that there were deleterious changes in the liver tissue such as dilated and congested central vein, inflammatory cell infiltration, cytoplasmic vaculation and pyknotic nucleus, cyto architecture disturbance, and degenerative changes more marked in the peripheral lobular areas of the liver tissue.

Keywords: Monosodium Glutamate, CPCSEA guideline, Schaumburg H.H and R. Byck.