Abstract

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 4-(MORPHOLIN- 4-YL) BENZOHYDRAZIDE DERIVATIVES

*M Somashekhar¹, Mahesh AR¹, Basavraj Sonnad²

ABSTRACT

We have chosen molecule having moieties possessing antimicrobial activity, one of which is hydrazide skeleton, which is reported to have antibacterial and antitubercular activity and other morpholine ring attached to 4th position of the benzene ring which possess the antibacterial, antimycobacterial and antifungal activity. Present work deals with the preparation of morpholie and 4-chloro-benzonitrile on reflux gives 4-(morpholine-4-yl) benzonitrile. this upon treating with sodium hydroxide gives 4-(morpholin-4-yl)benzoic acid. Then this upon treating with thionyl chloride gives 4-(morpholin-4-yl) benzoyl chloride. This on further treatment with hydrazine-hydrate gives 4- (morpholin-4-yl) benzohydrazide then it is treated with various substituted to form morpholine derivatives.Hydrazides were synthesized so as to increase intracellular concentration and so as to try and decrease the resistant developed due to decrease intracellular concentration of the drug. These synthesized compounds were subjected to preliminary biological evaluation. The characterization of synthesized compounds was identified on the basis of IR, 1HNMR, Mass spectroscopy. The compounds have been evaluated for antimicrobial activity.

Keywords: Morpholine, P-Chlorobenzonitrile, Antimicrobial activity, Intracellular concentration.