Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS JUNE ISSUE PUBLISHED
  • JUNE 2020 Issue has been successfully launched on 1 June 2020.

Abstract

FORMULATION AND EVALUATION OF LIPOSOMAL CARRIERS OF KETOCONAZOLE

*Shaik. Harun Rasheed1, N.Tirumooorthy2, Kundlik Girhepunje1

1Department of Pharmaceutics, NIMS University, Jaipur, Rajasthan, India.
2Department of Pharmaceutics, Cheran College of Pharmacy, Coimbatore, Tamilnadu, India.
3Department of Pharmaceutics, Peoples University, Bhopal, Madhya Pradesh, India.

ABSTRACT

Antifungal drug, Ketoconazole was encapsulated in liposomes for topical application. The main objective of the present work was to formulate and characterize the liposomal carrier containing ketoconazole and to investigate the drug delivery of ketoconazole drug having limited transdermal permeation. The liposomes were prepared by classical mechanical dispersion method and characterized for size, entrapment efficiency, skin penetration, vesicle skin interaction study. The practical size was determined by photocorrelation spectroscopy which was found to be 22215nm for empty vesicle and 26412nm for drug loaded vesicle, encapsulation efficiency was determined by dialysis technique (40.121.9%). Skin penetration can be determined by using confocal laser scanning microscopy (CLSM) (168 μm). Vesicle skin interaction study can be determined by using optical microscope. Our results indicate that ketoconazole loaded liposomal carrier could be better choice for the treatment of number of dermal infections.

Keywords: antifungal, Enhanced drug delivery, liposomes, ketoconazole, confocal laser scanning microscopy.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More