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FORMULATION AND EVALUATION OF LIPOSOMAL CARRIERS OF KETOCONAZOLE*Shaik. Harun Rasheed1, N.Tirumooorthy2, Kundlik Girhepunje1
1Department of Pharmaceutics, NIMS University, Jaipur, Rajasthan, India. 2Department of Pharmaceutics, Cheran College of Pharmacy, Coimbatore, Tamilnadu, India. 3Department of Pharmaceutics, Peoples University, Bhopal, Madhya Pradesh, India.
ABSTRACT Antifungal drug, Ketoconazole was encapsulated in liposomes for topical application. The main objective of the present work was to formulate and characterize the liposomal carrier containing ketoconazole and to investigate the drug delivery of ketoconazole drug having limited transdermal permeation. The liposomes were prepared by classical mechanical dispersion method and characterized for size, entrapment efficiency, skin penetration, vesicle skin interaction study. The practical size was determined by photocorrelation spectroscopy which was found to be 222±15nm for empty vesicle and 264±12nm for drug loaded vesicle, encapsulation efficiency was determined by dialysis technique (40.12±1.9%). Skin penetration can be determined by using confocal laser scanning microscopy (CLSM) (168 μm). Vesicle skin interaction study can be determined by using optical microscope. Our results indicate that ketoconazole loaded liposomal carrier could be better choice for the treatment of number of dermal infections. Keywords: antifungal, Enhanced drug delivery, liposomes, ketoconazole, confocal laser scanning microscopy. [Download Article] [Download Certifiate] |
