Abstract

DESIGN AND DEVELOPMENT OF PH AND TIME DEPENDENT RELEASE MODULATED MEBEVERINE COLON TARGETED SYSTEM

K. Ranjeeth Reddy*, M. Rajendar and G. Kiran

ABSTRACT

The aim of present study was to develop pH & time dependent colon targeted system of Mebeverine for effective application in the treatment of irritable bowel syndrome. In this study colon targeted systems are achieved by two different approaches. First approach was application of Hydroxy propyl methyl cellulose K4M (HPMC K4M) on core tablets by compression coating technique. These were further coated with Eudragit L100 at a coating level of 5 %w/w weight gain. Application of this high viscosity grade prolong the lag time greater than 8h, and were further optimized by using independent variables like concentration of HPMC & hydrophilic material in the outer coat. An increase in concentration of hydrophilic material decrease in the lag time of drug release was observed. The F1, F2 with 20%, 30% HPMC in the outer coat shows a lag time of 4.5h and 5 h respectively. In the second approach the core tablets with different concentration of superdisintegrant (to determine the effect of superdisintegrant on drug release from coated tablets) were coated with ethyl cellulose at different coating level and furthercoated with Eudragit L100 at a coating level of 10% w/w in order to optimize the drug release after a lag time 5h. The F5c, F7c containing without and with 5 % superdisintegrant&coated with ethyl cellulose at a coating level of 7.5% shows a lag time of between 5-5.5h, 5h and completely release the drug in 6.8 pH buffer in next 2h respectively.

Keywords: colon specific delivery, antispasmodic, superdisintegrant.