SEDATIVE PROPERTIES OF THE METHANOLIC EXTRACT OF CINNAMOMUM CECIDODAPHNE BARKS.
Naymul karim*, Limon kanti shill, Rana Dhar, Md Hossan sakib, Ahsan Ullah, Saiful Islam
ABSTRACT
Traditionally this plant used as a various types of diseases. The current
study was evaluated the in vivo sedative effect of the methanolic
fraction of Cinnamomum Cecidodaphne. The sedative activity was
tested by four method open field, hole cross, thiopental induced
sleeping time, EPM test at 200mg/kg and 400mg/kg on the Swiss
albino mice. For the comparing we used a standard drug thiopental
sodium. We saw the locomotors activity increased and the open field,
hole cross EPM test P<0.05 when orally administrated thiopental
sodium mice was maximized onset of sleep. The present study
revealed that the methanol fraction of the Cinnamomum Cecidodaphne
barks has significant sedative properties that may lead to new drug development.
Keywords: Cinnamomum Cecidodaphne, Sedative activity, Open field, Hole cross EPM test.
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