Abstract

EFFICACY AND SAFETY OF CLOBETASOL PROPIONATE SHAMPOO IN THERAPY OF PSORIASIS OF THE SCALP

Anna N. Platonova*, Andrey L. Bakulev, Sergey S. Kravchenya

ABSTRACT

Objectives: to evaluate the efficacy and safety of clobetasol propionate shampoo in patients with psoriasis lesions of the scalp in the acute phase. Materials and methods: Sixty patients with psoriasis of the scalp were enrolled and treated with 0.05% clobetasol propionate shampoo. All patients applied shampoo once daily for 15 minutes during 28 days. Evaluation of effectiveness was made on visit day 0, 7, 14, 21 and 28 using mPASI; TSS and the intensity of pruritus indexes. Safety of therapy was judged by the frequency of occurrence of any adverse effects. Results: It was shown that a daily 15-minute application of clobetasol propionate shampoo for 28 days promotes regression of psoriatic efflorescence of the scalp, decreasing of lesions area involvement approving statistically significant dynamics of dermatological index - mPASI; TSS; itching. A distinct therapeutic effect and absence of adverse effects promoted to a good compliance in patients with psoriasis of the scalp.

Keywords: psoriasis, therapy, clobetasol propionate, efficacy, safety.