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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

SIMULTANEOUS ESTIMATION OF GLIMEPIRIDE AND PIOGLITAZONE BY FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD IN BULK AND CAPSULE DOSAGE FORM

Hemant K. Jain*, Suchit D. Mule¹

¹Department of Quality Assurance Techniques, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune -411041, Maharashtra, India.

ABSTRACT

The present work describes first order derivative UV spectrophotometry for simultaneous estimation of Glimepiride (GLM) and Pioglitazone (PIO) in bulk drug and combined dosage form. Water: Acetonitrile (20:80) at pH 2.5 was used as a diluent. GLM and PIO were analysed at 268.73 nm and 226.72 nm, respectively using first order derivative Spectroscopy. This method was validated as per International Conference on Harmonization (ICH) guidelines. The values of correlation coefficient for GLM and PIO were 0.9996 and 0.9991, respectively. The percent recovery for GLM and PIO was in the range of 98.6-101.2% and 98.85-100.7%, respectively. Precision and result of assay of formulation were satisfactory. Statistical analyses for the results suggest that the method can be applied for the routine estimation of GLM and PIO in capsule dosage form.

Keywords: Glimepiride, Pioglitazone, Derivative Spectrophotometry, Simultaneous Estimation, Validation.

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