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Abstract

DETERMINATION OF CEFIXIME AND MOXIFLOXACIN IN PHARMACEUTICAL DOSAGE FORM BY SIMULTANEOUS EQUATION AND AREA UNDER CURVE UV-SPECTROPHOTOMETRIC METHOD

Mohammed Imran Anees*, Mirza Shahed Baig and Ashwini Tathe

ABSTRACT

Two simple, accurate and precise UV methods were developed for the estimation of Cefixime (CEF) and Moxifloxacin (MOXI) in Bulk and tablet dosage form. Both the drugs are used as Antimicrobial agents and in Respiratory tract infections. Method A is Simultaneous equation method; wavelengths selected for Quantitation were 293.0 nm for Cefixime (CEF) and 235.0 nm for Moxifloxacin (MOXI) respectively which are the λmax of both the drugs. Method B is AUC method in which wavelengths selected were 284-300 nm for Moxifloxacin and 225-250 nm for Cefixime. The Beer Lambert's law obeyed in the concentration range 2-12 μg/ml, with r2= 0.999 for both Moxifloxacin and Cefixime. The accuracy of the method was determined by recovery studies and it was found to be in the range of 99 to 100% for Cefixime and Moxifloxacin. The method showed good reproducibility and recovery with % RSD less than 2. The results of bulk drug analysis for method A is found to be 99.60 ± 0.82 S.D for CEF and 100.02 ±0.34 for MOXI and results obtained for Method B is 100.04 ±0.24 S.D for CEF and 99.70 ± 0.64S.D for MOXI. The proposed methods were successfully applied for the simultaneous determination of both the drugs in commercial tablet preparation. The results of the analysis have been validated as per ICH guidelines.

Keywords: Cefixime, Moxifloxacin, Simultaneous Equation method, Area under Curve method, UV Spectrophotometric method.


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