Abstract

FORMULATION AND EVALUATION STUDIES ON TRANSDERMAL DOSAGE FORMS OF DICLOFENAC SODIUM

Pilla Pavani Ganga Bhavani, Putta Rajesh Kumar*, Ravi Shankar.K,
Tata Santosh

ABSTRACT

The aim of the present study was to prepare and evaluate matrix type transdermal patches of Diclofenac sodium by using Hydroxy propyl methyl cellulose K15 (HPMCK15) and different grades of Eudragit (RL100, RS100, RLPO, RSPO) as polymers to minimize adverse effects associated with oral administration. Transdermal patches of Diclofenac sodium were prepared by solvent evaporation method by varying the blend ratios of HPMCK15 and Eudragit. The drug polymer interaction studies were carried out by FT-IR studies. The prepared patches were evaluated for their thickness, weight variation, folding endurance, percentage moisture absorption, percentage moisture loss and drug content. In vitro drug release was determined by using Franz diffusion cell in phosphate buffer (pH 7.4). The release data was studied for various kinetic parameters to understand the mechanism of drug release from the developed formulations. IR studies revealed that the drug, polymer and excipients were compatible with each other. Thin, flexible, smooth and uniform films were obtained with Eudragit and HPMC using dibutyl phthalate as plasticizer. Thickness, weights and drug contents of all the formulations remained almost uniform with low SD values. The formulations F7, F8 showed good release of drug than marketed formulation. Formulations contain Eudragit RLPO and HPMC K15, Eudragit RL100 and HPMC K15 showed good release when compared to the formulations contain Eudragit RSPO and HPMC K15. Studies have shown promising results and there is a scope for further pharmacokinetic evaluation.

Keywords: Diclofenac sodium, Hydroxy propyl methyl cellulose K15, Eudragit RL 100, RS100, RLPO, RSPO, Release Kinetics.