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Abstract

DETERMINATION OF LAMIVUDINE AND TENOFOVIR IN PHARMACEUTICAL DOSAGE FORM BY SIMULTANEOUS AND Q-ANALYSIS UV-SPECTROPHOTOMETRIC METHOD

Mohammed Imran Anees* and Mirza Shahed Baig

ABSTRACT

Two simple, accurate, precise, methods were developed for the estimation of Tenofovir and Lamivudine in Tablet dosage form. Both the drugs are used against the HIV infection as reverse transcriptase inhibitors. Method A is Simultaneous equation method, wavelength selected for Quantitation are 260.0 nm and 271.0 nm for Tenofovir (TEN) and Lamivudine (LAM) respectively which are the λmax of both the drugs. Method B is Q –Analysis method, wavelength selected were 260.0 nm (λmax of TEN) and 269.0 nm (Isobastic point) for the analysis. In both the methods linearity for detector response was observed in the concentration range of 10-60 microgram/ml for TEN and LAM respectively. The results of bulk drug analysis for Simultaneous equation method was found to be 99.37% + 0.396 S.D for LAM and 99.94% + 0.177 S.D for TEN and results obtained for Q –Analysis method was 99.65 ± 0.320 SD for LAM and 99.96 ± 0.568 SD for TEN. The proposed methods were successfully applied for the Simultaneous determination of both the drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies according to ICH guidelines.

Keywords: Tenofovir, Lamivudine, Simultaneous Equation method and Q-Analysis method, UV Spectrophotometric method.


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