WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

EVALUATION OF ACUTE AND SUB ACUTE TOXICITY OF STEM BARK AQUEOUS EXTRACT OF ANTHOCLEISTA SCHWEINFURTHII (LOGANIACEAE)

Christophe Mezui*, Frida Longo, Celine Nkenfou, Zacharie Sando, Emilie Ndeme, Paul Vernyuy Tan

ABSTRACT

Anthocleista schweinfurthii is a plant of the Loganiacea family. Many studies performed on it, related that the plant presents a wide variety of therapeutic effects, specially, cytoprotective effects on gastric mucosa, milky stimulator and anti-malarial virtues. This study aimed to evaluate the toxic profile of the aqueous extract obtained from the bark of this plant. Acute toxicity using a single dose of 2000 mg/kg was administered to mice and effects were observed for 14 days. The sub-acute toxicity of the aqueous extract at doses 250 mg/kg, 500 mg/kg and 1000 mg/kg, was also studied on male and female rats for 28 days. The control group, constituted of healthy rats, received the same amount of distilled water. At the end of the treatment, physical, haematological, biochemical and histological parameters were evaluated. The results obtained show no death and no significant variation (p>0, 05) in the behavioral and morphological parameters. Similarly, the sub acute test shows no significant variation, at all doses, in the evaluated parameters. In conclusion, the aqueous extract of the A. schweinfurthii can be classified in the category of non-toxic substances since its 50 % lethal dose (LD 50) is superior to 2000 mg/kg.

Keywords: toxicity, Anthocleista schweinfurthii, aqueous extract, Loganiaceae.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More