Abstract

SUSTAINED RELEASE MATRIX TYPE DRUG DELIVERY SYSTEM: A REVIEW

Ashish Sharma* and Vikas Bhatt

ABSTRACT

There is a continuously growing interest in the pharmaceutical industry for extended release oral drug delivery systems. There is also high interest for design of dosage formulations that allow high drug loading, particularly for actives with high water solubility. Conventional drug delivery systems are known to provide a prompt release of drug or immediate release drug product. Such immediate release products result in relatively rapid drug absorption and onset of accompanying pharmcodynamic effects. Hence, change in the operation is a suitable and optimized way to make the some drug more effective by slight alteration in the drug delivery. Sustained Release is also providing promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic concentration of the drug in the body. However after absorption of drug from is complete, plasma drug concentration decline according to the drugs pharmacokinetic profile. Pharmaceutical industries and academic laboratories have been focused on development of novel drug delivery system or modified release dosage form rather investigation and development of new drug. Advance in technology have resulted in novel modified release dosage form. In contrast to conventional form, modified release products provide either delayed release or extended release of drug.

Keywords: Conventional drug, water solubility, drugs pharmacokinetic, sustained release matrix type drug delivery.