Abstract

IBUPROFEN SELF-EMULSIFYING DRUG DELIVERY SYSTEM

Obitte Nicholas, Ugorji Lydia*, Ezichi Lawrence, Ogbodo Sunday, Onyishi Vegil and Chukwu Amarauche

ABSTRACT

Self emulsifying drug delivery system (SEDDS), which is an isotropic mixture of oil, surfactant with or without cosurfactant, can be used to improve the oral absorption of poorly soluble drugs such as ibuprofen. Therefore, the aim of this study was to formulate ibuprofen SEDDS and evaluate its in vitro and anti-inflammatory properties. Pseudo ternary phase diagram construction was carried out to identify stable formulations. Subsequently SEDDS were formulated using mixture of labrafac lipophile or its blend with peceol (oil), labrasol (surfactant) and lauroglycol 90 (co-surfactant). The following evaluations were carried out on the formulations: visual isotropicity, emulsification time, drug content, in vitro drug release, infinite aqueous dilution, post dilution drug precipitation and in vivo anti inflammatory tests respectively. Results showed that all the batches passed the visual isotropicity test, recorded emulsification time of less than a minute and promoted fast drug release. Infinite aqueous dilution showed no phase separation and in vivo anti inflammatory study demonstrated significantly higher anti-inflammatory activity (p<0.05) than ibuprofen powder. In conclusion, all the evaluations showed that the SEDDS improved the aqueous solubility of Ibuprofen and its anti-inflammatory activity.

Keywords: SEDDS, Labrasol®, Laurogycol® 90, Labrafac® lipophile, Ibuprofen.