Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF FUSED RING PYRIDOMORPHOLINE PHENOXY DERIVATIVES.

Loganathan velupillai*, M.S. Shingare and D.V. Mane

ABSTRACT

A series of seven novel 2-chloro-1-(2, 3-dihydro-4H-Pyrido[3, 2-b][1, 4] oxazin-4-yl) ethanone derivatives (II e - II k) were synthesized in multistep reaction from commercially available 2-amino-3-Hydroxy pyridine as a starting material. The chemical structures of the synthesized compounds were confirmed by means of 1HNMR and mass spectral data. High yield and high purity indicates lack of side reaction and by product. The synthesized compounds were then examined for their antibacterial and antifungal activities. Some of them were found to possess good antibacterial and antifungal activity.

Keywords: Synthesis, Fused morpholine, Phenoxy derivative, antibacterial, Antifungal activity.