Abstract

CONVOLVULUS PLURICAULIS CYTOPROTECTIVE ACTIVITY USING ABSOLUTE ALCOHOL INDUCED GASTRIC ULCER

Sharath S S, Preethy J, Surendra Kumar G, Revannaswamy A, Muralidhar P, Sujith Tumkur Rajashekar* and Rohini KR.

ABSTRACT

Introduction- Peptic ulcer disease is a chronic problem of the gastrointestinal tract characterized by mucosal damage secondary to pepsin and gastric acid secretion. Herbal medicines are generally used in cases when drugs are to be used for chronic periods. The study was conducted to evaluate antiulcerogenic activity of convolvulus pluricaulis in wistar rats. Methodology- The antiulcer activity was carried out employing - Absolute alcohol induced ulcer (Cytoprotective model). The rats were randomly divided into 4 groups of 6 animals each. First group was given 1ml of 0.1% of vehicle (Tween 80); the second group was treated with misoprostol 200μg/kg in 1 ml Tween 80. The remaining groups receive 200 mg/kg and 400 mg/kg of Convolvulus pluricaulis alcoholic extract (CPAE) in 1 ml Tween 80 respectively. All the drugs were administered orally for five days duration daily in two divided doses. Evaluation of antiulcer activity was done by Ulcer score/ulcer index. One way Anova followed by post hoc Dunnet's Test was used for statistical analysis. Results- The percentage of inhibition of ulcer with CPAE at a dose of 200 mg/kg and 400 mg/kg was 94.5% and 34.9% respectively and was statistically significant on comparison with control. Conclusions- Alcoholic extracts of Convolvulus pluricaulis have shown a significant protection against gastric ulcers in Absolute alcohol induced ulcer (Cytoprotective model).

Keywords: Convolvulus pluricaulis, Cytoprotective, Absolute alcohol induced ulcer model.