Abstract

PHYTOCHEMICAL SCREENING AND IN VIVO ANTIPYRETIC ACTIVITY OF THE AQUEOUS EXTRACT FROM MUCUNA PRURIENS

Uma S*, G. Ariharasivakumar #, Tamilarasan M and P. Gurumoorthi@

ABSTRACT

Background: The present study was designed and investigated the antipyretic activity of the aqueous extract of Mucuna pruriens seed (MPSE) in rats. Methods: Brewer’s yeast was used to induce fever in Wister rats which divided into four groups. The animal groups were administration of MPSE (200mg/kg and 400mg/kg, Paracetamol (reference standard, 150mg/kg) and 1% Tween 80(control) respectively. The rectal temperature of the rats was measured period of 5h. Result: Phytochemical screening was performed. MPSE (200mg/kg and 400mg/kg) was significantly decreased yeast induced pyrexia (p<0.05, p<0.01, p<0.001) respectively. Phytochemical analysis showed that the presence of alkaloids, tannins, phenols, flavanoids and saponins. Conclusion: The results indicate the aqueous extract of M.pruriens seed extract strongly significant antipyretic activity.

Keywords: Antipyretic activity, Brewer’s yeast, Mucuna pruriens, Paracetamol, Phytochemical screening.