Abstract

BRAIN TARGETING THROUGH NASAL ROUTE: AN OVERVIEW ON TRANSPORT MECHANISM, DELIVERY SYSTEMS AND EVALUATION

Sandhya Goyal¹, VishavPrabhjot Kaur¹, Lath Amit¹, Neha Dhawan¹, Saahil Arora*¹

¹Nanomedcine Research Center, ISF College of Pharmacy, Moga-1420001, India.

ABSTRACT

The nasal delivery is a innovative method for delivery of drug to brain by passing the blood brain barrier. As there are two pathways through which drug can be easily transferred to brain i.e by olfactory region or by trigeminal neuronal pathway. The drug delivery through nasal route ensures the sustained release effect and moreover the side effects caused by systemic delivery can be reduced to some extent. The nasal delivery is not showing its effect in acute or chronic disease but also helpful in local and systemic drug delivery and protection from microbial infections. There is no doubt that there are some disadvantages of nasal delivery but its successful delivery overcomes its all problems. The some general approaches like use of permeation enancers or absorption enhancers or by reducing the mucociliary clearance, enhancing its bioavailability delivery can be made efficient. This route is supposed to be substituted route to oral and parentral because of the promising administration of vaccines and biomolecules, that are vulnerable to enzymatic or acidic degradation and first pass hepatic metabolism. In last we can say that, it is more beneficial because of its tremendous advantages like non-invasiveness, self medication, patient comfort and patient compliance which are common hurdle in intravenous drug therapy.

Keywords: Mucociliary clearance, Permeation, Non-invasivenes.