Abstract

RECENT DEVELOPMENTS IN THE UNDERSTANDING AND DIAGNOSIS OF ALZHEIMER’S DISEASE: BIOMARKERS AND RISK FACTORS

Mohamedelbashir Abazar Elmamoon*, Routhu Prathyusha, Jahnavi Kotana, Hepsiba Kokkiligadda, K. Eswar Kumar

ABSTRACT

AD -Alzheimer's disease- is the leading cause of dementia with 60 -70 percent of all cases occurring world-wide, affecting an enormous number of individuals. It has a high economic burden on the social and the public health systems. AD is progressive in nature, and manifests itself by cognitive impairment, impaired memory and problems in day-to-day functioning. With the increase in disease incidence the urgent demand is to understand its underlying pathophysiology, improve diagnostic methods and come up with therapeutic strategies. The present detailed review examines the complicated mechanisms behind AD, evaluates the existing diagnostic procedures and the availability of new therapeutic options. The review aims to add to the current body of knowledge on this debilitating disease by explaining the complexities of this condition.

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