Abstract

COMPARATIVE IN VITRO EVALUATION OF IBUPROFEN200MG TABLETS SOLD IN PHARMACIES KHARTOUM SUDAN

Hamam Salih Badri Hamam*

ABSTRACT

Objective: The study was carried out to evaluate the quality of ibuprofen tablets sold in retail and wholesale pharmacies in Khartoum, sudan. Methods: The study was done for four different brands of ibuprofen (AB1, AB2, AB3 and AB4) obtained from different pharmacies in Khartoum, Sudan from local and international factories. The standard ibuprofen obtained from Shangahi-Sudan pharmaceutical. The properties of the tablets were evaluated by some tests in quality control laborataries, namely: uniformity of weight, thi ckness and diameter, friability, dissolution test and disintegration test.chromatographic method (HPLC) was used to determine the percentage of ibuprofen and to assay the tablets. These tests done according to united state pharmacopeia (BP). Results: We found that all the four different manufacturing brands are comply with BP requirements. Conclusion: All the Four brands of the ibuprofen tablets evaluated in this study could be regarded as being pharmaceutically and chemically equivalent.

Keywords: Brands, Ibuprofen Tablets Disintegration , Dissolution, Friability.