Photo Gallery



News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.



Vikas Bhatt *, Rajni Karakoti, Baby Bhatt, Arun Kumar Singh, Dinesh Kumar Sharma


The objective of present investigation was to isolate the phytochemical component, limonene from the peels of Citrus sinensis belonging to family Rutaceae and formulate anti-emetic nasal spray. Limonene loaded colloidal dispersion was prepared by using various polymers like HPMC, DSHOP, and surfactant as Tween 80. Further the formulation was evaluated for its clarity, pH, viscosity, pka, pump delivery, net content, and droplet diameters. Limonene was obtained by steam distillation method and subjected to its phytochemical screening and Pharmacopoeial procedures were used to study the, solubility, organoleptic properties, pH, viscosity, pka , pump delivery, net content, droplet diameters. The pH of the formulation was adjusted between 5.0-5.5 which is nonirritant for nasal delivery system. The result showed that the optimized formulation was found to be colorless, orange like odor and shows adhesive property. The adhesive property in the formulation is because of the presence of mucoadhesive polymer, which prolongs the effectiveness of dosages form by its mucoretentive effect onto the nasal mucosa. To evaluate the spray related property, a plastic spray container was selected and evaluated for the release of net content which was found to be 20 ml and total spray pattern of the formulation was found to be 322 sprays. The above study shows that the limonene loaded antiemetic formulation can be given via nasal route to enhance the effectiveness as well as onset of action.

Keywords: Limonene, HPMC, DSHOP, Steam distillation method, mucoadhesive polymer, mucoretentive effect.

[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More