Abstract

SCREENING OF METHANOLIC EXTRACT OF STERCULIA SCAPHIGERA WALL SEEDS FOR ULCERPROTECTIVE & ANTIOXIDANT ACTIVITY

Sunita C. Ogale*, Sanjay B. Kasture, Veena S. Kasture, Roshan Tiwari, Zaid Temrikar

ABSTRACT

In this study the antiulcer and antioxidant activity of methanolic extract & methanolic fraction of Sterculia scaphigera wall seeds (MESS & MFSS) was investigated. The methods used to induce ulcer were by physical method i.e. by pyloric-ligation (4 hr.) and by chemical method i.e. administering ethanol orally (40%,2ml/100gm, for 15 days, twice daily). Pretreatment of rats with the methanolic extract (50 mg/kg body weight,i.p.and p.o.) and methanolic fraction (25 and 50 mg/kg body weight, p.o.) of Sterculia scaphigera markedly reduced pyloric-ligation and ethanol - induced rise in volume of gastric acid secretion, total gastric acidity, pH of gastric content and ulcer index which was supported by the limited extent of histological damage.

Keywords: Sterculia scaphigera, Antioxidant, Antiulcer, Ethanol sunita ogale.