Abstract

RECENT INNOVATIONS OF NOVEL DRUG DELIVERY SYSTEMS FOR FORMULATION AND EVALUATION OF VITAMIN C AND VITAMIN E COSMECEUTICAL CREAM FOR STRETCH MARKS

Mahmoud Mahyoob Alburyhi*, Maged Alwan Noman and Abdalwali Ahmed Saif

ABSTRACT

Stretch marks, also known as striae distensae (SD), are visible linear scars that form in areas of dermal damage as a result of stretching of the skin. This study aims to develop an effective cream for the treatment of stretch marks using a blend of natural oils and vitamins. Key ingredients such as Vitamins E and C for their roles in promoting collagen production and improving skin elasticity also caffeine for improving blood flow, and a blend of natural oils were selected for their moisturizing and nourishing properties. The cream was formulated using advanced cosmetic techniques and evaluated through stability tests, microbial tests and clinical trials on a sample of volunteers with stretch marks in various body areas, also it showed a significant improvement in the appearance of stretch marks after of cream application, with increased skin elasticity and reduced depth of the marks. Additionally, the tests confirmed that the cream is safe for use, causing no irritation or side effects. The study concludes that this oil- and vitamin-based cream offers a promising solution for stretch ark treatment. It was concluded that the selected cream formulation F7 is the best formulation among all cream formulations NDDS emerged as the most effective and safe. Formulation scientist from his experience and knowledge have to significantly in the preformulation study stage and is an important factor in the NDDS (Novel Drug Delivery Systems) product development process.

Keywords: Vitamin C (Ascorbic acid), Vitamin E, NDDS, Development, Formulation, Creams, Stretch marks, Cosmeceutical.