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Abstract

COMPARATIVE EVALUATION OF RISEDRONATE SODIUM MUCOADHESIVE FILMS USING DIFFERENT MUCOADHESIVE POLYMERS

Dhrubojyoti Mukherjee* and Srinivasan Bharath

ABSTRACT

The aim of the study was to evaluate and characterize the properties of different mucoadhesive polymers in the development and formulation of mucoadhesive films with risedronate sodium, a highly water soluble drug. Films were prepared by solvent evaporation and solvent casting method. To characterize the different evaluation properties the films were prepared either by taking the mucoadhesive polymer individually or in combination. The mucoadhesive films were successfully prepared and demonstrated uniform and reproducible drug content (90.19±0.333 % to 98.72±0.658%), mass (0.087±0.022g to 0.115±0.023g), thickness (0.192±0.004 mm to 0.389 ±0.008 mm) mucoadhesivity (force of adhesion ranging from 0.195±0.097 N to 0.366±0.069 N and bond strength ranged from 8.689±0.589 Nm-2 to 19.877±0.761 Nm-2) followed by prolonged drug release profile. Films with polymeric blends exhibited optimum swelling property when compared to homopolymeric films. Most of the formulations swelled upto a period of 6 h and then erosion of the polymeric matrix took place. Films with a blend of chitosan and HPMC-4KM exhibited better mucoadhesive and drug release property which confirms the potential as a promising candidate for mucoadhesive delivery of risedronate sodium.

Keywords: mucoadhesion, solvent evaporation, risedronate sodium, chitosan, bioadhesive.


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