Abstract

FORMULATION AND EVALUATION ON NANO-ALOE BIO-BOOST ENTERIC COATED CAPSULES

Ms. Shiwani Ubale*, Ms. Amruta Gaikwad*, Ms. Shamal J. Kadam*

ABSTRACT

Background:- Aloe vera (Aloe barbadensis Miller) is one of the most valuable medicinal plants widely used in pharmaceutical, nutraceutical, cosmetic and traditional therapeutic applications due to its diverse phytochemical constituents such as flavonoids, tannins, polysaccharides, anthraquinones, vitamins and phenolic compounds. These bioactive compounds exhibit significant antioxidant, antimicrobial, anti-inflammatory, wound-healing and gastroprotective properties. However, instability of phytoconstituents and poor targeted delivery often reduce therapeutic efficiency. Nano-based enhancement strategies and enteric coated dosage forms can improve drug protection, bioavailability, and controlled release characteristics. Therefore, development of a Nano-Aloe Bio-Boost enteric coated capsule may provide improved pharmaceutical effectiveness andstability.[1] Materials and Methods:- Fresh Aloe vera leaves were collected and processed for extraction of bioactive gel. The extract was dried and formulated into capsule dosage form using excipients including microcrystalline cellulose, talc and magnesium stearate to improve flowability, compressibility and filling properties. Powder blend was passed through appropriate sieves to eliminate lumps and ensure uniform mixing. Capsules were prepared using capsule filling techniques followed by enteric coating to protect active constituents from acidic gastric degradation. Various evaluation parameters such as organoleptic characteristics, flow properties, weight variation, disintegration behavior, dissolution profile and drug release study were performed. Comparative pharmaceutical performance was analyzed to determine formulation efficiency.[2] Results:- The prepared Nano-Aloe Bio-Boost enteric coated capsule demonstrated acceptable physical appearance, satisfactory powder flow properties, and uniform capsule filling behavior. Weight variation was found within pharmacopeial limits indicating formulation consistency. Enteric coating significantly delayed capsule disintegration in acidic medium while ensuring release in intestinal pH. Dissolution analysis showed approximately 83.3% drug release, indicating efficient release kinetics and enhanced stability of phytoconstituents. The formulation exhibited improved pharmaceutical acceptability and may support better therapeutic delivery of Aloe vera bioactive compounds.[3]

Keywords: Aloe vera; Nano formulation; Enteric coated capsule; Phytochemical constituents; Antioxidant activity; Antimicrobial activity; Drug release; Herbal dosage form; Pharmaceutical evaluation; Bioavailability enhancement.