Abstract

INTEGRATION OF AI IN DIGITAL ANALYTICAL METHOD DEVELOPMENT AND VALIDATION PROCESS FOR METFORMIN HCL AND EMPAGLIFLOZIN

Mahesh N. Pingale*, Pooja M. Salunke, Supriya N. Sabale, Sabiya A. Shaikh, Nirmiti N. Shetepatil, Mukta S. Shikhare

ABSTRACT

Stability indicating UV -spectrophotometric method is simple, an accurate and economic, precise and reproducible method has been used for the estimation of Metformin HCL (MET HCL) and Empagliflozin (EMPA) in bulk and tablets dosage form in present work. Mobile Phase ratio used for working standard is Water: ethanol (60:40). The wavelength selected for the absorption correction method was (MET HCL) 233nm and (EMPA) 224nm. The linearity range of (MET HCL) 2-8μg/ml and (EMPA) 0.5-2μg/ml proved that it obeyed Beer’s Law and the correlation coefficient (r2) was found to be MET HCL 1 at 233 nm and EMPA 0.9998 at 224nm.

Keywords: Antidiabetic, UV Spectroscopy, Metformin Hydrochloride, Empagliflozin, Method Validation.