Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2020 Issue has been successfully launched on 1 February 2020.

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Abstract

NOVEL DEHYDROACETIC ACID BASED HYDRAZONE SCHIFF’S BASE METAL COMPLEXES OF FIRST TRANSITION SERIES: SYNTHESIS AND BIOLOGICAL EVALUATION STUDY

A. K. Gupta*, R. Pal, V. Beniwal

ABSTRACT

In search of a new series of potential biologically active agents, syntheses of metal complexes of dehydroacetic acid (DHA) based tridentate hydrazone Schiff’s base that is 4-Hydroxy-N'-(1-(4-hydroxy-5-methyl-2-oxo-2H-pyran-3-yl)ethylidene)benzohydrazide (PDLH) with Co(II), Ni(II), Cu(II), Mn(II) Zn(II) has been achieved successfully. The Schiff‘s base was prepared by treating DHA with 4-hydroxybenzoylhydrazide under reflux in methanol. All the synthesized compounds were characterized on the basis of the results obtained from elemental analysis, 1H and 13C NMR, IR, UV visible spectroscopy, mass spectrometry and conductance. IR spectra of complexes revealed that ligand coordinated through N and O donor atoms. The mass spectrum of complexes also supported the formation of desired compounds. The UV visible spectrum revealed that complexes adopted octahedral geometry around the metal ions for all the synthesized compounds. Finally, all the synthesized compounds were tested for DNA photocleavage activities using plasmid DNA and anti-bacterial potential against four pathogenic strains of bacteria. In general metal complexes were found to be more potent biological agents as compared to ligand under the identical experimental condition and Cu(II) complex, particularly was found to exhibit potential nuclease and anti-bacterial activities.

Keywords: Schiff’s base, DHA, metal complexes, DNA photocleavage study, anti-bacterial study.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More