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Abstract

UNDERSTANDING OF PROTEIN-LIGAND INTERACTION FOR BREAST AND LUNG CANCER COMPOUNDS USING DOCKING METHOD

T. Panduranga Vital*, G.S.V. Prasada Raju, D.S.V.G.K. Kaladhar

ABSTRACT

Proteins are structural and fundamental components which are directly or indirectly related with the functioning of an organism. There are more number of breast and lung cancers patients that are predicted in the previous literature. The ATM (ataxia telangiectasia mutated) and CHEK2 (checkpoint kinase 2) have the strongest evidence of being related to the risk of developing breast cancer. EGFR and BRAF have the evidence of being related to the risk of developing breast cancer. AKT1 and PIK3CA are linked to both breast and lung cancers. The Docking studies with selected compounds like Carmofur, Fenretinide, Crizotinib, Docetaxel, Flavipiridol, Gemcitabine, Bexarotene, Floxuridine and Satraplatin has been conducted using iGEMDOCK. The docking results provided good scope for Docetaxel compound as anticanNcer drug for both lung and breast cancers.

Keywords: Docking, lung and breast cancers.


[Full Text Article]

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