Abstract

A REVIEW ON MORINGA OLIFERA EFFERVESCENT TABLET FOR ANTIANEMIC ACTIVITY

Uddhav Jejurkar*, Tushar Jagdale, Vishal Sonawane, Harshal Patil, Rahul Arote

ABSTRACT

The D-optimal mix design was utilized in the new product development process of the Moringa oleifera effervescent tablet to optimize the acid-base ratio in the recipe. The antioxidant activity and chemical profile of the Moringa oleifera extract were assessed. Measurements were made on the physicochemical and sensory properties of the effervescent Moringa oleifera tablet. Because moringa leaves, which are a component of the Moringa Oleifera plant, have a high antioxidant content, they help the body fight off free radicals. Additionally, the contents of the leaves may be turned into effervescent granules, a functional drink. The kind and proportion of the effervescent agent have a significant impact on the granule's physical properties, stability, and acceptability. Because they both offer a texture and mouthfeel that is acceptable, sodium bicarbonate and citric acid were employed as the effervescent agents in this investigation. Three formulations (designated as F1, F2, and F3) with varying ratios of citric acid to sodium bicarbonate were chosen. Moringa oleifera leaves, seeds, bark, roots, sap, and flowers are widely used in traditional medicine, and the leaves and immature seed pods are used as food products in human nutrition. Leaf extracts exhibit the greatest antioxidant activity, and various safety studies in animals involving aqueous leaf extracts indicate a high degree of safety. No adverse effects were reported in association with human studies. Five human studies using powdered whole leaf preparations of M. oleifera have been published, which have demonstrated anti-hyperglycemic (antidiabetic) and anti-dyslipidemic activities. These activities have been confirmed using extracts as well as leaf powders in animal studies. A rapidly growing number of published studies have shown that aqueous, hydroalcohol, or alcohol extracts of M. oleifera leaves possess a wide range of additional biological activities including antioxidant, tissue protective (liver, kidneys, heart, testes, and lungs), analgesic, antiulcer, antihypertensive, radioprotective, and immunomodulatory actions. A wide variety of polyphenols and phenolic acids as well as flavonoids, glucosinolates, and possibly alkaloids is believed to be responsible for the observed effects. Standardization of products is an issue. However, the results of published studies to date involving M. oleifera are very promising. Additional human studies using standardized extracts are highly desirable. © 2015 The Authors Phytotherapy Research Published by John Wiley & Sons Ltd. The wet granulation process was used to create these formulations. The three formulations' effervescent granules demonstrated good particle size distribution and flow capabilities. According to the results of the organoleptic and sensory evaluation, formulation F3 was the most palatable in terms of texture, taste, color, and scent. Furthermore, an extract from Moringa oleifera displayed IC50 values of 320µg/ml. Acceptability-wise, all of the recipes had a somewhat bitter taste, which could be attributed to the extract's tannins and phenolic components. Addition of flavoring agents, such as lemon and strawberry, is unable to mask the bitter taste of the final tablet. Here in, the first Moringa leaves effervescent tablet prepared using wet granulation was successfully formulated.

Keywords: moringa olifera, D-optimal mix design, aroma, extract.