Abstract

FORMULATION AND EVALUATION OF PUDINA GRANULES

Ms. Nikita Sandeep Manjare*, Prof. Hina A. Momin, Dr. Sampat D. Navale, Afrin Abdul Shaikh

ABSTRACT

Herbal formulations have gained considerable importance in recent years due to their natural origin, improved safety profile, and better patient compliance compared to synthetic preparations. Among various medicinal herbs, pudina (Mentha arvensis) is one of the most commonly used aromatic plants because of its cooling sensation, digestive properties, refreshing flavor, and therapeutic benefits. Pudina contains essential oils such as menthol, menthone, and flavonoids that contribute to its carminative, antispasmodic, antimicrobial, and antioxidant activities. Traditionally, pudina has been used in the management of indigestion, nausea, vomiting, gastric irritation, bad breath, and minor respiratory discomfort. The present research work was aimed at the formulation and evaluation of herbal pudina granules as a stable, palatable, and convenient oral dosage form suitable for routine use. The granules were prepared using dried pudina leaf powder along with suitable excipients including sweetening agents, binders, flavoring agents, and diluents to improve taste, flowability, and overall acceptability. The wet granulation method was selected for the preparation of granules because of its simplicity, cost-effectiveness, and ability to produce uniform granules with better mechanical strength. During the formulation process, the powdered ingredients were blended uniformly and converted into moist mass using a binding solution, followed by sieving, drying, and size reduction to obtain free-flowing granules. Proper precautions were taken to preserve the volatile constituents of pudina during drying and storage. The prepared granules were subjected to various evaluation parameters to determine their pharmaceutical quality and performance. Organoleptic characteristics such as color, odor, taste, texture, and appearance were examined to assess consumer acceptability. The granules exhibited a characteristic green color with a pleasant aromatic odor and cooling taste, indicating successful incorporation of pudina without significant loss of volatile components. The flow properties of the granules were evaluated using angle of repose, bulk density, tapped density, Carr’s compressibility index, and Hausner ratio. The obtained values indicated satisfactory flow behavior and compressibility, demonstrating that the prepared granules were suitable for handling, packaging, and storage. Moisture content analysis revealed that the granules possessed optimum dryness, which is essential for maintaining stability and preventing microbial growth. Particle size distribution studies showed uniform granule formation, which may contribute to improved dissolution and consistent dosing. Solubility and dispersibility tests indicated that the granules dispersed rapidly in water and produced a refreshing herbal solution with acceptable clarity and taste. The pH of the prepared formulation was found to be within an acceptable range for oral administration and was considered non-irritating to the gastrointestinal tract. The stability study of pudina granules was carried out under suitable storage conditions to evaluate changes in physical appearance, odor, taste, and flow properties over a defined period. The formulation remained stable without any significant changes in color, caking, moisture absorption, or loss of aroma, indicating good stability characteristics. The presence of natural phytoconstituents in pudina may also contribute to antioxidant and preservative effects, thereby improving shelf life. In addition, the herbal granules were found to be easy to administer, portable, and more convenient compared to traditional decoctions or fresh herbal preparations.

Keywords: Mentha piperita, herbal extract, wet granulation, effervescent granules, phytochemical screening, essential oils, pharmaceutical formulation, flow properties, dissolution time.