Abstract

ESTIMATION OF T3, T4 AND TSH AND URINARY IODINE CONCENTRATION OF PREGNANT WOMEN FROM THE RURAL AREAS AROUND PUNE REGION, MAHARASHTRA, INDIA

N.S. Rajurkar*, Neeta Zatakia, S.F. Patil

ABSTRACT

Iodine is essential for the production of thyroid hormones by thyroid gland and these hormones are important for development of fetus’s brain. Iodine deficiency in the fetus is the result of iodine deficiency in the mother. The consequence of iodine deficiency during pregnancy is impaired synthesis of thyroid hormones by the mother which results in an insufficient supply of thyroid hormones to the developing brain of the fetus which may result in mental retardation. Taking into consideration importance of iodine during pregnancy we have analyzed urine and blood samples of 71 pregnant women of different trimesters from rural area around Pune region to check urinary iodine concentration, triiodothyronine, thyroxine and thyroid stimulating hormone. Chemometric analysis of obtained results was carried out using SPSS version 20.

Keywords: Sandell-Kolthoff reaction, radioimmunoassay, triiodothyronine, thyroxine, thyroid stimulating hormone, hypothyroidism.