Abstract

INFLAMMATORY BIOMARKER IN DIABETES: A LINK BETWEEN INFLAMMATION AND METABOLIC DYSFUNCTION

Km Monee*, Navneet Pratap Singh

ABSTRACT

Diabetes mellitus (DM) is a common long-term metabolic problem. India has the most cases of DM in the world. Type 1 diabetes mellitus (T1DM) is primarily caused by the autoimmune destruction of pancreatic β-cells, while type 2 diabetes mellitus (T2DM) is characterized by a resistance to insulin and β-cell malfunction. nephropathy, retinopathy, neuropathy, cardiovascular disease, and diabetic foot ulcers are among the serious side effects that might result from either type. the onset and progression of diabetes mellitus are significantly influenced by persistent low-grade inflammation, according to recent data. Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), C-reactive protein (CRP), and interleukin-1 beta (IL-1β) are key biomarkers that link dysregulated immune responses to metabolic disorders. Disease development is fueled by molecular pathways that worsen oxidative stress and insulin resistance, such as NF-κB, JNK, and the NLRP3 inflammasome. a number of new biomarkers, in addition to well-known ones, have demonstrated potential for enhancing early diagnosis and individualized treatment. they offer further information about the metabolic and inflammatory interactions in diabetes mellitus. these include soluble CD163, gut microbiota-derived metabolites, high mobility group box 1 (HMGB1), and microRNAs. Biomarker discovery is also being accelerated by the introduction of multi-omics technology and AI-driven data analytics. These methods make it possible to precisely stratify patients and make it easier to develop medications that are specifically targeted. diabetes care is being revolutionized by biomarker research. novel biomarkers that associate inflammation with metabolic dysfunction allow for early diagnosis, monitoring, and targeted therapy. this shifts diabetes care toward precision-based treatment methods and ultimately advances personalized medicine.

Keywords: Diabetes mellitus, Inflammation, Cytokines, NF-?B, MicroRNAs, Precision medicine.