Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2020 Issue has been successfully launched on 1 February 2020.

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Abstract

FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE OPTIZORB DISPERSIBLE TABLET TO IMPROVE TABLET DISINTEGRATION

B. Lavanya* and V. Shanmugam

ABSTRACT

The present research work was aimed the formulation and evaluation of OptiZorb dispersible tablets of bisoprolol fumarate, an antihypertensive agent. The OptiZorb technology is based on the use of excipients of Alginic acid and calcium carbonate. Alginic acid absorbs lot of water, swells and leads to decay effect brought about. Calcium carbonate reacts with the stomach acid, within 3 minutes it releases 90% of the active ingredient this compared with only 10-15% in marketed paracetamol. Optizorb technology is five times faster in tablet disintegration and thus gets to work much more quickly. Dispersible tablets were prepared by wet granulation method by using Alginic acid and calcium carbonate as disintegrants in different concentrations. Compatibility studies of drug and excipients were carried out by using FT- IR spectroscopy and DSC. The formulations were evaluated for precompressional parameters such as bulk density, tapped density, angle of repose, Carr’s index and Hausner’s ratio. The tablets were evaluated for weight variation, thickness, hardness, friability, drug content, dispersion time, disintegration time and invitro dissolution study. Invitro dissolution studies were performed by using USP dissolution apparatus type II paddle in 900 ml of 0.1N Hydrochloric acid at 50 rpm. No chemical interaction between drug and excipients was confirmed by FTIR studies. After study of all formulations F9 showed short dispersion time with maximum drug release in 15 min and it contains Alginic acid and calcium carbonate (1:1).

Keywords: Alginic acid, antihypertensive, Bisoprolol fumarate, calcium carbonate, dispersible tablet, OptiZorb technology.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More